Christopher Raub, Ph.D.
Ph.D., Biomedical Engineering, University of California, Irvine, 2009
M.S., Biomedical Engineering, University of California, Irvine, 2006
B.S., Biology, Harvey Mudd College, 2004
Biography in Brief:
Dr. Raub’s research goal is to determine microscale mechanisms of tissue injury, remodeling, and repair, with insights that lead to novel diagnostic and therapeutic strategies. To achieve this objective, Dr. Raub’s laboratory is designed to merge tissue engineering, biomedical optics, and microfluidics to noninvasively capture cell and matrix dynamics in 3-D, and relate microscale features to macroscale tissue mechanics. Using similar approaches in the past, Dr. Raub has analyzed the influence of extracellular matrix microstructure on bulk mechanical properties of engineered tissue, pulmonary airways following epithelial injury, and articular cartilage during knee joint degeneration and surgical repair. This work occurred during his doctoral studies at the University of California, Irvine, from 2004-2009, and his postdoctoral work at the University of California, San Diego, from 2009-2013. From 2013-2014, Dr. Raub pursued a capstone postdoctoral experience at the Keck School of Medicine, University of Southern California, developing microfluidic assays for the detection of cancer mutations. Moving forward, the unifying theme of Dr. Raub’s research will be noninvasive assessment of and control over cell and matrix dynamics to inhibit pathologic and guide therapeutic remodeling of collagen-rich tissues.
Refereed Journal Papers
Raub CB, Hsu SC, Chan EF, Chen AC, Truncale KG, Semler EJ, Chnari E, and RL Sah. Microstructural remodeling of articular cartilage following defect repair by osteochondral autograft transfer. Osteoarthritis and Cartilage. 21(6):860-8, 2013.
Stender ME, Raub CB, Yamauchi K, Shirazi R, Vena P, Sah RL, Hazelwood SJ, and SM Klisch. TGF-β1 and IGF-1 modulate articular cartilage collagen fiber modulus: continuous anisotropic fiber distribution FEA using qPLM, biochemical assay, and mechanical test data. Journal of Biomechanics. 12(6):1073-88, 2013.
Raub CB, Mahon S, Narula N, Tromberg BJ, Brenner M, and SC George. Linking optics and mechanics in an in vivo model of airway fibrosis and epithelial injury. Journal of Biomedical Optics. 15(1):015004, 2010.
Kreuter KA, Mahon SB, Mukai DS, Su J, Jung WG, Narula N, Guo S, Wakida N, Raub CB, Berns MW, George SC, Chen Z , and M Brenner. Detection and monitoring of early airway injury effects of half-mustard (2-chloroethylethylsulfide) exposure using high resolution optical coherence tomography. Journal of Biomedical Optics. 14(4):044037, 2009.
Malavia NK, Raub CB, Mahon SB, Brenner M, Panattieri RA Jr, and SC George. Airway epithelium stimulates smooth muscle proliferation. American Journal of Respiratory Cell and Molecular Biology. 41(3):297-304, 2009.
Malavia NK, Mih JD, Raub CB, Dinh BT, and SC George. IL-13 induces a bronchial epithelial phenotype that is profibrotic. Respiratory Research. 9(1):27, 2008.
Raub CB, Unruh J, Suresh V, Krasieva T, Lindmo T, Gratton E, Tromberg BJ, and SC George. Image correlation spectroscopy of multiphoton images correlates with collagen mechanical properties. Biophysical Journal. 94(6):2361-73, 2008.
Ghajar CM, Suresh V, Peyton SR, Raub CB, Meyskens FL Jr., George SC, and AJ Putnam. A novel three-dimensional model to quantify metastatic melanoma invasion. Molecular Cancer Therapeutics. 6(2):552-61, 2007.
Raub CB, Suresh V, Krasieva T, Lyubovitsky J, Mih JD, Putnam AJ, Tromberg BJ, and SC George. Noninvasive assessment of collagen gel microstructure and mechanics using multiphoton microscopy. Biophysical Journal. 92(6):2212-22, 2007.
Peyton S, Raub CB, Keshrumrus V, and AJ Putnam. The use of poly(ethylene glycol) hydrogels to investigate the impact of ECM chemistry and mechanics on smooth muscle cells. Biomaterials. 27(28):4881-93, 2006.
Raub CB, Tromberg BJ, and SC George: Second harmonic generation imaging of self-assembled collagen gels. In: Second Harmonic Generation Imaging, ed by FS Pavone and PJ Campagnola, Taylor and Francis, 2014.